骨佩吉特病：一种破骨细胞疾病。
Paget's disease of bone: a disease of the osteoclast.
作者信息
Reddy S V, Kurihara N, Menaa C, Roodman G D
机构信息
Department of Medicine, Division of Hematology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX, USA.
出版信息
Rev Endocr Metab Disord. 2001 Apr;2(2):195-201. doi: 10.1023/a:1010010912302.
Paget's disease is a chronic focal disease of the skeleton that affects up to 2-3% of the population over the age of 60 years. There is a genetic predisposition for Paget's disease, with one predisposition locus identified on chromosome 18q-21-22. Osteoclasts and osteoclast precursors from Paget's patients are abnormal and appear hyperresponsive to 1,25(OH)2D3 and RANK ligand and contain paramyxoviral transcripts (Fig. 1). The basis for the abnormalities detected in Paget's disease and the role that the paramyxoviruses may play in this disease are still unclear.
佩吉特病是一种骨骼的慢性局灶性疾病，在60岁以上人群中的发病率高达2%至3%。佩吉特病存在遗传易感性，在18号染色体q21 - 22区域已确定一个易感位点。佩吉特病患者的破骨细胞及破骨细胞前体异常，对1,25(OH)₂D₃和RANK配体表现出高反应性，且含有副粘病毒转录物（图1）。佩吉特病中检测到的异常情况的基础以及副粘病毒在该疾病中可能发挥的作用仍不清楚。
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