Synthesis and study of glutaryl-S-(omega-aminoalkyl)-L-cysteinylglycines as inhibitors of glyoxalase I.

Glutaryl-S-(8-aminooctyl)-L-cysteinylglycine and glutaryl -S-(10-aminodecyl)-L-cysteinylglycine have been prepared by a seven-step procedure as potential ligands for affinity chromatography purification of mouse liver glyoxalase I. Both compounds exhibited nonlinear, mixed-type inhibition of the enzyme. The decyl derivative was a more effective inhibitor than was the octyl analog.