Wahab P J, Hopman W P, Jansen J B
Department of Gastroenterology and Hepatology, University Hospital Nijmegen, The Netherlands.
Dig Dis Sci. 2001 Nov;46(11):2504-9. doi: 10.1023/a:1012344424300.
The distal gut hormone peptide YY (PYY) mediates feedback inhibition of gastric acid secretion, gastrointestinal motility, and pancreatic enzyme output. To investigate the influence of maldigestion on PYY, we determined plasma PYY levels in patients with celiac disease under basal conditions and in response to intraduodenal fat. Basal PYY was increased in untreated celiac patients (N = 13) compared to patients on a gluten free diet (N = 9) [15.6 (11.8-27.0) pM vs 12.2 (10.1-13.1) pM; P < 0.05] and compared to control subjects (N = 15) [9.5 (8.3-10.4) pM; P < 0.001]. Integrated PYY in response to intraduodenally infused predigested fat (1071+/-293 pM 80 min) was significantly (P < 0.05) greater than in response to undigested fat (322+/-223 pM 80 min) in six untreated celiacs. Plasma concentrations of PYY and cholecystokinin were strongly correlated (r = 0.79; P < 0.001). We conclude that basal PYY levels in untreated celiac disease are elevated, that predigestion of fat enhances PYY release in these patients, and that PYY secretion is correlated with CCK release.
远端肠激素肽YY（PYY）介导胃酸分泌、胃肠动力及胰腺酶分泌的反馈性抑制。为研究消化功能不良对PYY的影响，我们测定了乳糜泻患者在基础状态下及十二指肠内注入脂肪后的血浆PYY水平。与接受无麸质饮食的患者（N = 9）相比，未经治疗的乳糜泻患者（N = 13）基础状态下的PYY水平升高[15.6（11.8 - 27.0）pM对12.2（10.1 - 13.1）pM；P < 0.05]，与对照组受试者（N = 15）相比也升高[9.5（8.3 - 10.4）pM；P < 0.001]。在6例未经治疗的乳糜泻患者中，十二指肠内注入预先消化的脂肪后80分钟的PYY积分（1071±293 pM）显著高于注入未消化脂肪后的积分（322±223 pM 80分钟）（P < 0.05）。血浆PYY和胆囊收缩素的浓度呈强相关（r = 0.79；P < 0.001）。我们得出结论，未经治疗的乳糜泻患者基础状态下的PYY水平升高，脂肪预先消化可增强这些患者的PYY释放，且PYY分泌与CCK释放相关。
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