克拉司甾醇，一种从海绵类动物克拉氏属物种中提取的新型抗HIV-1逆转录酶硫酸化甾醇。

Clathsterol, a novel anti-HIV-1 RT sulfated sterol from the sponge Clathria species.

作者信息

Rudi A, Yosief T, Loya S, Hizi A, Schleyer M, Kashman Y

机构信息

School of Chemistry and School of Medicine, Tel-Aviv University, Ramat-Aviv 69978, Israel.

出版信息

J Nat Prod. 2001 Nov;64(11):1451-3. doi: 10.1021/np010121s.

DOI:10.1021/np010121s

PMID:11720531

Abstract

As part of a search for novel inhibitors of humandeficiency virus type 1 (HIV-1) reverse transcriptase (RT), the MeOH-EtOAc extract of a Red Sea sponge, Clathria sp., was shown to be active. Bioassay-guided fractionation of the extract yielded a novel sterol sulfate, clathsterol (1), which is responsible for the activity and is active at a concentration of 10 microM. The structure of 1 was established mainly by interpretation of spectral data and a chemical transformation.

摘要

作为寻找新型人类免疫缺陷病毒1型（HIV-1）逆转录酶（RT）抑制剂的一部分，红海海绵Clathria sp.的甲醇-乙酸乙酯提取物显示具有活性。对该提取物进行生物测定导向的分级分离得到了一种新型甾醇硫酸盐，即clathsterol（1），它具有该活性，在浓度为10微摩尔时具有活性。1的结构主要通过光谱数据的解释和化学转化得以确定。