适度饮酒与怀孕等待时间

Moderate alcohol consumption and waiting time to pregnancy.

作者信息

Juhl M, Nyboe Andersen A M, Grønbaek M, Olsen J

机构信息

Danish Epidemiology Science Centre at the Department of Epidemiology Research, Statens Serum Institut, 5, Artillerivej, DK-2300 Copenhagen S, Denmark.

出版信息

Hum Reprod. 2001 Dec;16(12):2705-9. doi: 10.1093/humrep/16.12.2705.

DOI:10.1093/humrep/16.12.2705

PMID:11726599

Abstract

BACKGROUND

Recent research indicates that even a moderate consumption of alcohol in women trying to become pregnant is associated with longer waiting time to pregnancy. The findings, though, are based upon few observations.

METHODS

Self-reported data on alcohol intake and waiting time to pregnancy (0-2, 3-5, 6-12 and >12 months) was used for 39 612 pregnant women, recruited to the Danish National Birth Cohort within the first 24 weeks of pregnancy from 1997 to 2000. Main outcome measures were odds ratios (OR) for a prolonged waiting time to pregnancy according to alcohol intake.

RESULTS

In nulliparous women neither moderate nor high alcohol intake was related with longer waiting time to pregnancy compared with a low intake. In parous women, a modest association was seen only among those with an intake of >14 drinks per week (subfecundity OR 1.3; 95% confidence interval 1.0-1.7). Women who reported no alcohol intake had a slightly longer waiting time (subfecundity OR 1.2; 95% confidence interval 1.1-1.3) than women with a moderate intake of alcohol.

CONCLUSIONS

Our findings do not corroborate recent results suggesting a marked reduction in fecundity associated with a moderate intake of alcohol.

摘要

背景

近期研究表明，即使是试图怀孕的女性适度饮酒也与更长的受孕等待时间有关。然而，这些发现基于较少的观察结果。

方法

对1997年至2000年怀孕前24周内招募到丹麦国家出生队列的39612名孕妇，使用了关于酒精摄入量和受孕等待时间（0 - 2个月、3 - 5个月、6 - 12个月和超过12个月）的自我报告数据。主要结局指标是根据酒精摄入量计算的受孕等待时间延长的比值比（OR）。

结果

与低酒精摄入量相比，未生育女性的适度或高酒精摄入量均与更长的受孕等待时间无关。在经产妇中，仅在每周饮酒超过14杯的人群中观察到适度关联（生育力低下OR为1.3；95%置信区间为1.0 - 1.7）。报告不饮酒的女性比适度饮酒的女性受孕等待时间略长（生育力低下OR为1.2；95%置信区间为1.1 - 1.3）。