白细胞介素-7增强多发性硬化症中T细胞对髓鞘蛋白的反应。

IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis.

作者信息

Traggiai E, Biagioli T, Rosati E, Ballerini C, Mazzanti B, Ben Nun A, Massacesi L, Vergelli M

机构信息

Department Neurological and Psychiatric Sciences, Viale Pieraccini 6, 50134, Florence, Italy.

出版信息

J Neuroimmunol. 2001 Dec 3;121(1-2):111-9. doi: 10.1016/s0165-5728(01)00433-7.

DOI:10.1016/s0165-5728(01)00433-7

PMID:11730947

Abstract

In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease. In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.

摘要

在本研究中，我们调查了多发性硬化症（MS）患者和对照组外周血T淋巴细胞在不存在或存在调节因子白细胞介素-7（IL-7）的情况下对髓鞘碱性蛋白（MBP）和髓鞘少突胶质细胞糖蛋白（MOG）的体外增殖反应。在不存在IL-7的情况下，MS患者和对照组对MOG和MBP的T细胞反应性相似，即使在患有活动性疾病的患者亚组中发现对MBP的反应有所增加。在存在IL-7的情况下，MS患者中观察到对MBP的T细胞反应性增加，这表明他们的MBP特异性T细胞处于不同的功能状态。