Lephart E D, Adlercreutz H, Lund T D
Neuroscience Center, Brigham Young University, Provo, UT 84602, USA.
Neuroreport. 2001 Nov 16;12(16):3451-5. doi: 10.1097/00001756-200111160-00015.
Phytoestrogens are estrogen-like (plant-derived) molecules that protect against age-related diseases (cardiovascular disease and osteoporosis), hormone-dependent (breast and prostate) cancers and selectively bind estrogen receptors. However, little is known about the influence of phytoestrogens on brain. Using diets containing either high phytoestrogen levels, derived from soy, or very low phytoestrogens we quantified phytoestrogen concentrations of daidzein, genistein and equol in brain. We found that dietary phytoestrogens: significantly decrease body and prostate weights, do not alter brain aromatase levels and significantly change during adulthood the structure of the sexually dimorphic brain region (i.e. anteroventral periventricular nucleus; AVPV) in male, but not in female rats. Since most commercial animal diets contain significant concentrations of phytoestrogens their influence on brain structure should be considered.
植物雌激素是一类类似雌激素（源自植物）的分子，可预防与年龄相关的疾病（心血管疾病和骨质疏松症）、激素依赖性（乳腺癌和前列腺癌）癌症，并能选择性地结合雌激素受体。然而，关于植物雌激素对大脑的影响，我们所知甚少。我们使用了含有高植物雌激素水平（源自大豆）或极低植物雌激素的饮食，对大脑中大豆苷元、染料木黄酮和雌马酚的植物雌激素浓度进行了量化。我们发现，饮食中的植物雌激素：显著降低体重和前列腺重量，不改变大脑芳香化酶水平，并且在成年期会显著改变雄性大鼠而非雌性大鼠的性二态脑区（即腹侧室旁核；AVPV）的结构。由于大多数商业动物饲料都含有大量植物雌激素，因此应考虑它们对大脑结构的影响。
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