Rho家族小G蛋白在钙黏蛋白介导的细胞间黏附中的作用

Rho-family GTPases in cadherin-mediated cell-cell adhesion.

作者信息

Fukata M, Kaibuchi K

机构信息

Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, 466-8550, Japan.

出版信息

Nat Rev Mol Cell Biol. 2001 Dec;2(12):887-97. doi: 10.1038/35103068.

DOI:10.1038/35103068

PMID:11733768

Abstract

Cell-cell adhesions are rearranged dynamically during tissue development and tumour metastasis. Recently, Rho-family GTPases, including RhoA, Rac1 and Cdc42, have emerged as key regulators of cadherin-mediated cell-cell adhesion. Following the identification and characterization of regulators and effectors of Rho GTPases, signal transduction pathways from cadherin to Rho GTPases and, in turn, from Rho GTPases to cadherin, are beginning to be clarified.

摘要

在组织发育和肿瘤转移过程中，细胞间黏附会动态重排。最近，包括RhoA、Rac1和Cdc42在内的Rho家族小GTP酶已成为钙黏蛋白介导的细胞间黏附的关键调节因子。随着Rho GTP酶调节因子和效应器的鉴定与表征，从钙黏蛋白到Rho GTP酶，进而从Rho GTP酶到钙黏蛋白的信号转导通路开始得以阐明。