King B R, Smith R, Nicholson R C
Mothers and Babies Research Centre, University of Newcastle, 2305, Newcastle, NSW, Australia
Peptides. 2001 Nov;22(11):1941-7. doi: 10.1016/s0196-9781(01)00486-7.
Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to the determination of gestational length in the human. Although encoded by a single copy gene, CRH expression in the placenta is regulated differently to the hypothalamus. Glucocorticoids stimulate CRH promoter activity in the placenta but inhibit it's activity in the hypothalamus, via mechanisms involving different regions of the CRH promoter. We discuss how various stimuli alter CRH promoter activity and why these responses are unique to the placenta.
促肾上腺皮质激素释放激素（CRH）是一种由41个氨基酸组成的神经肽，在下丘脑和人类胎盘中表达。胎盘CRH的产生与人类妊娠期的确定有关。尽管CRH由单拷贝基因编码，但胎盘和下丘脑中CRH的表达调控方式不同。糖皮质激素通过涉及CRH启动子不同区域的机制，刺激胎盘CRH启动子的活性，但抑制下丘脑CRH启动子的活性。我们讨论了各种刺激如何改变CRH启动子的活性，以及为什么这些反应是胎盘所特有的。
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