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吗啡对人体血清生长激素、皮质醇、催乳素及促甲状腺激素的影响。

Effects of morphine on serum growth hormone, cortisol, prolactin and thyroid stimulating hormone in man.

作者信息

Tolis G, Hickey J, Guyda H

出版信息

J Clin Endocrinol Metab. 1975 Oct;41(4):797-800. doi: 10.1210/jcem-41-4-797.

DOI:10.1210/jcem-41-4-797
PMID:1176587
Abstract

Morphine administration in man results in a significant increase in serum prolactin without altering the levels of growth hormone, thyroid stimulating hormone and cortisol. Apomorphine prevented the morphine induced prolactin rise. It is suggested that the effect on prolactin is not mediated via non specific stress or changes in the thyroid stimulating hormone releasing factor, but via suppression prolactin inhibiting factor or activation of a specific prolactin releasing factor.

摘要

在人体中注射吗啡会导致血清催乳素显著增加，而不会改变生长激素、促甲状腺激素和皮质醇的水平。阿扑吗啡可防止吗啡诱导的催乳素升高。研究表明，对催乳素的影响不是通过非特异性应激或促甲状腺激素释放因子的变化介导的，而是通过抑制催乳素抑制因子或激活特定的催乳素释放因子介导的。

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引用本文的文献

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J Endocrinol Invest. 1981 Jan-Mar;4(1):31-6. doi: 10.1007/BF03349410.
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[Prolonged functional disturbance of prolactin secretion after surgery under neuroleptanalgesia].[神经安定镇痛下手术后催乳素分泌的长期功能紊乱]
Can Anaesth Soc J. 1982 Sep;29(5):468-72. doi: 10.1007/BF03009410.
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