红车轴草（Trifolium pratense）在去卵巢的Sprague-Dawley大鼠体内表现出雌激素样作用。
Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats.
作者信息
Burdette Joanna E, Liu Jianghua, Lantvit Dan, Lim Eula, Booth Nancy, Bhat Krishna P L, Hedayat Samad, Van Breemen Richard B, Constantinou Andreas I, Pezzuto John M, Farnsworth Norman R, Bolton Judy L
机构信息
Department of Medicinal Chemistry and Pharmacognosy and UIC/National Institutes of Health Center for Botanical and Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
出版信息
J Nutr. 2002 Jan;132(1):27-30. doi: 10.1093/jn/132.1.27.
Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones was administered by gavage [250, 500 and 750 mg/(kg x d)] to virgin, ovariectomized 50-d-old Sprague-Dawley rats, for 21 d in the presence and absence of 17beta-estradiol [50 microg/(kg x d)]. Estrogenic effects included an increase in uterine weight, vaginal cell cornification and mammary gland duct branching. Red clover produced a dose-dependent increase in uterine weight and differentiated vaginal cells at the two higher doses, but it did not stimulate cell proliferation in the mammary glands. Neither antiestrogenic nor additive estrogenic properties were observed in any of the tissues studied. These data suggest that red clover extract is weakly estrogenic in the ovariectomized rat model.
利用去卵巢大鼠模型开展研究，以确定红车轴草提取物的雌激素活性和抗雌激素活性。将一种标准化后含15%异黄酮的红车轴草提取物，通过灌胃法给予50日龄处女去卵巢斯普拉格-道利大鼠[250、500和750毫克/（千克×天）]，在有和没有17β-雌二醇[50微克/（千克×天）]的情况下给药21天。雌激素作用包括子宫重量增加、阴道细胞角化和乳腺导管分支。红车轴草在两个较高剂量时使子宫重量呈剂量依赖性增加并使阴道细胞分化，但未刺激乳腺细胞增殖。在所研究的任何组织中均未观察到抗雌激素或相加雌激素特性。这些数据表明，在去卵巢大鼠模型中红车轴草提取物具有弱雌激素活性。
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