Hurst Bradley S, Tucker Kathleen E, Schlaff William D
Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado, USA.
Fertil Steril. 2002 Jan;77(1):98-100. doi: 10.1016/s0015-0282(01)02956-9.
To determine if a fixed-dose stimulation protocol with monitoring limited to a single ultrasound can provide acceptable outcomes in assisted reproduction technologies (ART) procedures in appropriately selected patients.
Prospective study of all minimally monitored ART cycles from 1996 through 1998.
University ART program.
Eligibility included Institutional Review Board consent, age 18-37, basal FSH < or = 10, normal semen parameters, and regular menses. IVF (n = 81) and GIFT (n = 14).
A single ultrasound was performed after 8 or 9 days of stimulation in a fixed-schedule long luteal phase leuprolide protocol. No hormone levels were obtained. Human chorionic gonadotropin was administered when at least 2 follicles were projected to reach 18 mm.
Pregnancy, delivery, and implantation rates.
The clinical pregnancy rates were 51% for IVF and 36% for GIFT. Delivery rates were 42% for IVF and 29% for GIFT. The implantation rates for IVF were 23% and 17% for GIFT. No patient was admitted for ovarian hyperstimulation.
We were able to achieve satisfactory pregnancy and delivery rates in properly selected patients with a minimal monitoring protocol, limited to a single ultrasound near the end of a fixed-stimulation regimen. The reduced time commitment and cost led to a very high patient acceptance of this approach.
确定在适当选择的患者中，采用固定剂量刺激方案并仅通过单次超声监测，能否在辅助生殖技术（ART）程序中取得可接受的结果。
对1996年至1998年所有最少监测的ART周期进行前瞻性研究。
大学ART项目。
入选标准包括获得机构审查委员会同意、年龄18 - 37岁、基础促卵泡激素（FSH）≤10、精液参数正常且月经规律。体外受精（IVF）患者81例，配子输卵管内移植（GIFT）患者14例。
在固定日程的长黄体期亮丙瑞林方案刺激8或9天后进行单次超声检查。未获取激素水平。当预计至少有2个卵泡达到18毫米时给予人绒毛膜促性腺激素。
妊娠率、分娩率和着床率。
IVF的临床妊娠率为51%，GIFT为36%。IVF的分娩率为42%，GIFT为29%。IVF的着床率为23%，GIFT为17%。无患者因卵巢过度刺激而入院。
我们能够在适当选择的患者中，通过最少的监测方案（仅限于固定刺激方案接近尾声时的单次超声检查）实现令人满意的妊娠率和分娩率。时间投入和成本的降低导致患者对这种方法的接受度非常高。
Zotero 插件