β-连环蛋白在肾细胞癌中的表达。
Expression of beta-catenin in renal cell carcinoma.
作者信息
Zang T, Zhuang L, Zhang Z, Xin D, Guo Y
机构信息
Department of Urology, First Hospital, Beijing Medical University, Institute of Urology, Beijing 100034, China.
出版信息
Chin Med J (Engl). 2001 Feb;114(2):152-4.
OBJECTIVE
To investigate the expression of beta-catenin and its mRNA in renal cell carcinoma.
METHODS
Twenty-six cases with renal cell carcinoma (RCC) were studied by immunohistochemistry, Western blot and RT-PCR.
RESULTS
We found the expression of beta-catenis is higher in cancer tissues than in normal kidney tissues and the level of beta-catenin is associated with the tumor stage. Its expression in tumor of pT3 and pT4 is obviously higher than pT1 and pT2 (P < 0.01). That is to say, there was an overexpression of beta-catenin protein in RCC and its level was related to the tumor stage, but the expression of beta-catenin mRNA had no difference between tumor tissue and normal tissue.
CONCLUSION
beta-catenin may be related to the occurrence and progress of RCC.
目的
研究β-连环蛋白及其mRNA在肾细胞癌中的表达情况。
方法
采用免疫组织化学、蛋白质免疫印迹法及逆转录-聚合酶链反应（RT-PCR）对26例肾细胞癌患者进行研究。
结果
我们发现β-连环蛋白在癌组织中的表达高于正常肾组织，且β-连环蛋白水平与肿瘤分期相关。其在pT3和pT4期肿瘤中的表达明显高于pT1和pT2期（P < 0.01）。也就是说，肾细胞癌中β-连环蛋白蛋白存在过表达，且其水平与肿瘤分期有关，但β-连环蛋白mRNA在肿瘤组织和正常组织中的表达无差异。
结论
β-连环蛋白可能与肾细胞癌的发生及进展有关。
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