Cordell H J, Dudbridge F
Dept. of Medical Genetics, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge CB2 2XY, UK.
Genet Epidemiol. 2001;21 Suppl 1:S510-5. doi: 10.1002/gepi.2001.21.s1.s510.
A variety of allele-sharing methods was used to assess linkage to disease for a whole-genome screen in each of ten replicates from the Genetic Analysis Workshop 12 simulated data. Analysis of each replicate produced many false positive results in addition to a few "true" positives. Conditioning on the strongest initial linkage and reanalyzing using a variety of conditional methods did not improve the power for detection or help discriminate between true and false positive signals.