Semple S E, Proud L A, Tannahill S N, Tindall M E, Cherrie J W
Department of Environmental and Occupational Medicine, University of Aberdeen, Liberty Safe Work Research Centre, United Kingdom.
Scand J Work Environ Health. 2001 Dec;27(6):395-401. doi: 10.5271/sjweh.632.
This study examined whether it is possible to train occupational hygienists to estimate inhalation exposures reliably from limited occupational information using a new method and assessed improvements in the quality of the estimate using the aggregate from multiple assessors.
Five occupational hygienists estimated inhalation exposure for 40 tasks covering a range of chemical hazards using a recently developed subjective modeling technique supplemented by detailed guidance notes. The measured exposure levels were used to determine the validity of the method. The correlation coefficients of the log-transformed data were used to assess the discriminative power of the method, and the ratio of the mean estimate to measured values was used to measure accuracy.
There was good-to-excellent agreement between the assessors' estimates and the measured data, the correlation coefficients ranging from 0.73 to 0.85. There was a tendency for assessors to overestimate the exposure levels by, on the average, two- to fourfold. Aggregating the assessors' estimates helped to improve the correlation coefficient to 0.88, the overestimation being 2.6-fold. Using more than three assessors for aggregate estimates did not improve the reliability of the method.
Overall, the assessors found the method to be useful in generating exposure estimates that correlate well with measured levels. The provision of high-quality guidance information is likely to be important in the generation of reliable exposure estimates. The method is likely to be of use in epidemiologic studies in which limited exposure data are available.
本研究探讨是否有可能培训职业卫生学家使用一种新方法从有限的职业信息中可靠地估计吸入暴露量,并使用多个评估者的汇总数据评估估计质量的改进情况。
五名职业卫生学家使用最近开发的主观建模技术并辅以详细的指导说明,对涵盖一系列化学危害的40项任务的吸入暴露量进行了估计。测量的暴露水平用于确定该方法的有效性。对数转换后数据的相关系数用于评估该方法的辨别力,平均估计值与测量值的比率用于衡量准确性。
评估者的估计值与测量数据之间存在良好至优秀的一致性,相关系数范围为0.73至0.85。评估者有高估暴露水平的趋势,平均高估两到四倍。汇总评估者的估计值有助于将相关系数提高到0.88,高估倍数为2.6倍。使用超过三名评估者进行汇总估计并没有提高该方法的可靠性。
总体而言,评估者发现该方法有助于生成与测量水平相关性良好的暴露估计值。提供高质量的指导信息可能对生成可靠的暴露估计值很重要。该方法可能适用于可获得有限暴露数据的流行病学研究。