Schindler A E
Am J Obstet Gynecol. 1975 Oct 1;123(3):265-8. doi: 10.1016/0002-9378(75)90196-9.
The conversion of androstenedione to estrone in various tissues of 13 human fetuses ranging from 9 to 40 weeks of gestation was measured by a double isotope method in vitro. The data revealed differences in aromatization between cerebrum and hypothalamus. For hypothalamic tissue the conversion rate ranged between 0.01 and 1.40 per cent and for cerebral tissue between 0.00 and 0.07 per cent. The highest rate of conversion was found in liver tissue. Adrenal, kidney, lung, thymus, heart, skin, and gut were also examined and the results are compared with data in the literature.
采用双同位素体外测定法，对13例妊娠9至40周的人类胎儿不同组织中雄烯二酮向雌酮的转化情况进行了测定。数据显示大脑和下丘脑的芳香化作用存在差异。下丘脑组织的转化率在0.01%至1.40%之间，大脑组织的转化率在0.00%至0.07%之间。肝脏组织的转化率最高。还对肾上腺、肾脏、肺、胸腺、心脏、皮肤和肠道进行了检测，并将结果与文献中的数据进行了比较。
