巴西圣保罗州不同社会行为的两组儿童中的水痘传播情况。
Varicella transmission in two samples of children with different social behaviour in the State of São Paulo, Brazil.
作者信息
Yu A L, Amaku M, Burattini M N, Massad E, Azevedo R S
机构信息
LIM 01/HCFMUSP, School of Medicine, University of São Paulo, Brazil.
出版信息
Epidemiol Infect. 2001 Dec;127(3):493-500. doi: 10.1017/s0950268801006124.
In order to establish the differences in transmission pattern of varicella-zoster virus (VZV), a comparative seroepidemiological study was carried out in two different children samples. Children aged 1-11 years, were randomly selected from state schools of São Paulo city, Brazil. Individuals aged 1-15 years were sampled by cluster from Caieiras city. Children aged 3 years or under from Caieiras were not attending school, while those from São Paulo were attending all-day nurseries or kindergarten. The presence of antibodies to VZV was analysed by ELISA technique. The force of infection and contact rate were determined by mathematical techniques. The average age of first infection was 2.87 +/- 0.14 years and 4.07 +/- 0.47 years for Sao Paulo and Caieiras, respectively. The average force of infection estimated was 0.29 year(-1) for São Paulo and was 0.26 year(-1) for Caieiras. The proportion of seropositivity and the force of infection were higher in São Paulo school children up to 3 years of age compared with Caieiras children, where the social contact starts later. In conclusion, social changes affecting contact among children may influence varicella epidemiology.
为了确定水痘带状疱疹病毒（VZV）传播模式的差异，在两个不同的儿童样本中进行了一项比较血清流行病学研究。1至11岁的儿童从巴西圣保罗市的公立学校中随机选取。1至15岁的个体通过整群抽样从凯埃拉斯市选取。凯埃拉斯市3岁及以下的儿童未上学，而圣保罗市的儿童在全日制托儿所或幼儿园就读。采用酶联免疫吸附测定（ELISA）技术分析VZV抗体的存在情况。通过数学技术确定感染率和接触率。圣保罗市和凯埃拉斯市首次感染的平均年龄分别为2.87±0.14岁和4.07±0.47岁。估计圣保罗市的平均感染率为0.29年⁻¹，凯埃拉斯市为0.26年⁻¹。与社交接触开始较晚的凯埃拉斯市儿童相比，3岁及以下的圣保罗市学童血清阳性率和感染率更高。总之，影响儿童之间接触的社会变化可能会影响水痘流行病学。
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