基于吩嗪的双拓扑异构酶I/II抑制剂XR11576类似物的构效关系
Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576.
作者信息
Wang Shouming, Miller Warren, Milton John, Vicker Nigel, Stewart Alistair, Charlton Peter, Mistry Prakash, Hardick David, Denny William A
机构信息
Department of Medicinal Chemistry, Xenova Ltd., 957 Buckingham Avenue, Slough, Berkshire SL1 4NL, UK.
出版信息
Bioorg Med Chem Lett. 2002 Feb 11;12(3):415-8. doi: 10.1016/s0960-894x(01)00770-3.
Abstract
As part of a programme to identify further analogues of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various 'minimal' and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576.
摘要
作为寻找双拓扑异构酶I/II抑制剂XR11576更多类似物计划的一部分，我们在此描述了XR11576菲嗪模板的各种“最小化”和3,4-苯并稠合菲嗪发色团的合成及构效关系研究。
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