肯尼亚的艾滋病毒与宫颈癌
HIV and cervical cancer in Kenya.
作者信息
Gichangi P, De Vuyst H, Estambale B, Rogo K, Bwayo J, Temmerman M
机构信息
Department of Obstetrics and Gynecology, University of Nairobi, Nairobi, Kenya.
出版信息
Int J Gynaecol Obstet. 2002 Jan;76(1):55-63. doi: 10.1016/s0020-7292(01)00560-4.
OBJECTIVES
To determine the effect of the HIV epidemic on invasive cervical cancer in Kenya.
METHODS
Of the 3902 women who were diagnosed with reproductive tract malignancies at Kenyatta National Hospital (KNH) from 1989 to 1998, 85% had invasive cervical cancer. Age at presentation and severity of cervical cancer were studied for a 9-year period when national HIV prevalence went from 5% to 5-10%, to 10-15%.
RESULTS
There was no significant change in either age at presentation or severity of cervical cancer. Of the 118 (5%) women who were tested for HIV, 36 (31%) were seropositive. These women were 5 years younger at presentation than HIV-negative women.
CONCLUSIONS
A two- to three-fold increase in HIV prevalence in Kenya did not seem to have a proportional effect on the incidence of cervical cancer. Yet, HIV-positive women who presented with cervical cancer were significantly younger than HIV-negative women.
目的
确定肯尼亚艾滋病流行对浸润性宫颈癌的影响。
方法
1989年至1998年在肯雅塔国家医院（KNH）被诊断为生殖道恶性肿瘤的3902名女性中，85%患有浸润性宫颈癌。在全国艾滋病病毒流行率从5%升至5%-10%，再升至10%-15%的9年期间，对就诊年龄和宫颈癌严重程度进行了研究。
结果
就诊年龄和宫颈癌严重程度均无显著变化。在接受艾滋病病毒检测的118名（5%）女性中，36名（31%）血清呈阳性。这些女性就诊时比艾滋病病毒阴性女性年轻5岁。
结论
肯尼亚艾滋病病毒流行率增加两到三倍似乎对宫颈癌发病率没有成比例的影响。然而，患宫颈癌的艾滋病病毒阳性女性明显比艾滋病病毒阴性女性年轻。
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