促凋亡基因Bax在胃癌中的表达及意义
Expression and significance of proapoptotic gene Bax in gastric carcinoma.
作者信息
Liu Hai-Feng, Liu Wei-Wen, Fang Dian-Chun, Men Rong-Pu
出版信息
World J Gastroenterol. 1999 Feb;5(1):15-17. doi: 10.3748/wjg.v5.i1.15.
AIM
To study the expression of proapoptotic gene Bax in human gastric carcinoma and its significance.METHODS:Using immunohistochemistry methods, the Bax protein expression in 57 specimens of gastric carcinoma and its relationship with clinical status and pathomorphological parameters were observed.RESULTS:Thirty- three (57.9%) cases were positive for Bax protein staining which was mainly located in the cytoplasm of tumor cells. The rate of Bax protein expression was not correlated with the tumor size, lymph node metastasis, depth of invasion, clinical stages of tumors and age and sex of patients (P >0.05), but strongly associated with the morphological type and differentiation degree of tumors. It was significantly higher in intestinal type and well or moderately differentiated gastric carcinoma than in diffuse type and poorly differentiated gastric carcinoma (P < 0.05 and P <0.01).CONCLUSION:The proapoptotic gene Bax is differently expressed in most of gastric carcinoma and may take part in the modulation of apoptosis in gastric carcinoma. The expression of Bax might be associated with the occurrence of intestinal type gastric carcinoma and the differentiation of gastric carcinoma.
目的
研究促凋亡基因Bax在人胃癌中的表达及其意义。方法：采用免疫组织化学方法，观察57例胃癌标本中Bax蛋白的表达情况及其与临床状况和病理形态学参数的关系。结果：33例（57.9%）Bax蛋白染色呈阳性，主要位于肿瘤细胞的细胞质中。Bax蛋白表达率与肿瘤大小、淋巴结转移、浸润深度、肿瘤临床分期及患者年龄、性别无关（P>0.05），但与肿瘤的形态类型和分化程度密切相关。肠型及高、中分化胃癌中的表达明显高于弥漫型及低分化胃癌（P<0.05和P<0.01）。结论：促凋亡基因Bax在大多数胃癌中表达不同，可能参与胃癌细胞凋亡的调控。Bax的表达可能与肠型胃癌的发生及胃癌的分化有关。
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