Fleming Michael F, Mundt Marlon P, French Michael T, Manwell Linda Baier, Stauffacher Ellyn A, Barry Kristen Lawton
Department of Family Medicine, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53715, USA.
Alcohol Clin Exp Res. 2002 Jan;26(1):36-43.
This report describes the 48-month efficacy and benefit-cost analysis of Project TrEAT (Trial for Early Alcohol Treatment), a randomized controlled trial of brief physician advice for the treatment of problem drinking.
Four hundred eighty-two men and 292 women, ages 18-65, were randomly assigned to a control (n = 382) or intervention (n = 392) group. The intervention consisted of two physician visits and two nurse follow-up phone calls. Intervention components included a review of normative drinking, patient-specific alcohol effects, a worksheet on drinking cues, drinking diary cards, and a drinking agreement in the form of a prescription.
Subjects in the treatment group exhibited significant reductions (p < 0.01) in 7-day alcohol use, number of binge drinking episodes, and frequency of excessive drinking as compared with the control group. The effect occurred within 6 months of the intervention and was maintained over the 48-month follow-up period. The treatment sample also experienced fewer days of hospitalization (p = 0.05) and fewer emergency department visits (p = 0.08). Seven deaths occurred in the control group and three in the treatment group. The benefit-cost analysis suggests a 43,000 dollars reduction in future health care costs for every 10,000 dollars invested in early intervention. The benefit-cost ratio increases when including the societal benefits of fewer motor vehicle events and crimes.
The long-term follow-up of Project TrEAT provides the first direct evidence that brief physician advice is associated with sustained reductions in alcohol use, health care utilization, motor vehicle events, and associated costs. The report suggests that a patient's personal physician can successfully treat alcohol problems and endorses the implementation of alcohol screening and brief intervention in the US health care system.
本报告描述了“早期酒精治疗试验”(TrEAT项目)的48个月疗效及效益成本分析,该项目是一项针对问题饮酒治疗的简短医生建议的随机对照试验。
482名年龄在18至65岁之间的男性和292名女性被随机分配到对照组(n = 382)或干预组(n = 392)。干预措施包括两次医生问诊和两次护士随访电话。干预内容包括对正常饮酒情况的回顾、患者特定的酒精影响、饮酒提示工作表、饮酒日记卡以及处方形式的饮酒协议。
与对照组相比,治疗组受试者在7天饮酒量、暴饮次数和过度饮酒频率方面均有显著降低(p < 0.01)。这种效果在干预后6个月内出现,并在48个月的随访期内得以维持。治疗组的住院天数也较少(p = 0.05),急诊就诊次数也较少(p = 0.08)。对照组有7人死亡,治疗组有3人死亡。效益成本分析表明,每投资10,000美元进行早期干预,未来医疗保健成本可降低43,000美元。若将机动车事故和犯罪减少带来的社会效益纳入考量,效益成本比会增加。
TrEAT项目的长期随访提供了首个直接证据,表明简短的医生建议与酒精使用、医疗保健利用率、机动车事故及相关成本的持续降低相关。该报告表明,患者的私人医生能够成功治疗酒精问题,并支持在美国医疗保健系统中实施酒精筛查和简短干预。