Zhu Jian-xin, Zhang Yao-ming
Department of Orthopedic Surgery, Sichuan Provincial People's Hospital, Chengdu Scihuan, P. R. China 610071.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 Jan;16(1):42-3.
To observe the effect of recombinant human epidermal growth factor (rhEGF) on healing of chronic ulcer wound.
From January 1999 to January 2001, twenty-six patients with chronic wounds were adopted in this study. Among them, there were 17 males and 9 females, aged from 12 to 61 years. The area of the chronic wound varied from 3 cm x 3 cm to 5 cm x 8 cm and the disease course was 7 to 16 days. These patients were treated with rhEGF in the way of sprinkling locally (400 U/10 cm2). Another 26 patients with chronic wounds were adopted as the control group and were treated with 0.9% saline in the same way. The healing time of wounds and the local and systemic reactions of patients were observed.
The healing time of chronic wounds was shorter obviously to about 7 days with rhEGF than that of the control group and there was significant difference between the two groups(P < 0.01).
rhEGF can obviously promote the healing of chronic ulcer wound.
观察重组人表皮生长因子（rhEGF）对慢性溃疡创面愈合的影响。
1999年1月至2001年1月，本研究纳入26例慢性创面患者。其中，男性17例，女性9例，年龄12至61岁。慢性创面面积为3 cm×3 cm至5 cm×8 cm，病程7至16天。这些患者采用rhEGF局部喷洒（400 U/10 cm²）的方式进行治疗。另外选取26例慢性创面患者作为对照组，采用相同方式给予0.9%生理盐水治疗。观察创面愈合时间以及患者的局部和全身反应。
使用rhEGF治疗的慢性创面愈合时间明显缩短至约7天，与对照组相比差异有统计学意义（P < 0.01）。
rhEGF能明显促进慢性溃疡创面的愈合。
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