尼可地尔与氨氯地平对异丙肾上腺素诱导的大鼠心肌梗死线粒体功能的协同作用。

Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol-induced myocardial infarction in rats.

作者信息

Sathish Venkatachalem, Vimal Veereshwarayya, Ebenezar Kesavarao Kumar, Devaki Thiruvengadam

机构信息

Department of Biochemistry and Molecular Biology, University of Madras, Chennai, India.

出版信息

J Pharm Pharmacol. 2002 Jan;54(1):133-7. doi: 10.1211/0022357021771841.

DOI:10.1211/0022357021771841

PMID:11829124

Abstract

The synergistic effects of nicorandil (KATP-channel opener) and amlodipine (calcium-channel blocker) on heart mitochondrial enzymes and the mitochondrial antioxidant defence system was examined on isoproterenol-induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for two days showed significant changes in marker enzymes, mitochondrial enzymes and the mitochondrial defence system. Pre-co-treatment with nicorandil (2.5 mg kg(-1) daily, p.o.) and amlodipine (5.0 mg kg(-1) daily, p.o.) for 3 days significantly prevented these alterations and restored enzyme activity to near normal. These findings demonstrate the protective and synergistic effect of nicorandil and amlodipine in combination against isoproterenol-induced cardiac damage.

摘要

研究了尼可地尔（一种钾离子通道开放剂）和氨氯地平（一种钙通道阻滞剂）对异丙肾上腺素诱导的大鼠心肌梗死模型中心肌线粒体酶及线粒体抗氧化防御系统的协同作用。连续两天腹腔注射异丙肾上腺素（150 mg kg⁻¹）的大鼠，其标志酶、线粒体酶及线粒体防御系统均出现显著变化。预先连续3天口服尼可地尔（2.5 mg kg⁻¹）和氨氯地平（5.0 mg kg⁻¹）可显著预防这些改变，并使酶活性恢复至接近正常水平。这些结果表明，尼可地尔和氨氯地平联合使用对异丙肾上腺素诱导的心脏损伤具有保护和协同作用。