hKAP1.6和hKAP1.7这两种新型人类高硫角蛋白相关蛋白在毛囊皮质中表达。
hKAP1.6 and hKAP1.7, two novel human high sulfur keratin-associated proteins are expressed in the hair follicle cortex.
作者信息
Shimomura Yutaka, Aoki Noriaki, Rogers Michael A, Langbein Lutz, Schweizer Jürgen, Ito Masaaki
机构信息
Department of Dermatology, Niigata University School of Medicine, Asahimachi-dori, Niigata, Japan.
出版信息
J Invest Dermatol. 2002 Feb;118(2):226-31. doi: 10.1046/j.0022-202x.2001.01653.x.
Hair fiber differentiation involves the expression of both hair keratin intermediate filament proteins and their associated proteins, termed keratin-associated proteins. In this study, cDNA clones encoding two novel keratin-associated proteins were isolated from human hair follicle mRNA. The predicted amino acid sequence derived from these clones revealed that these proteins represent members of the human keratin-associated protein 1 family. They show strong sequence homology to two previously described keratin-associated protein 1 family members hKAP1.1 A and hKAP1.1B. We have called these new proteins hKAP1.6 and hKAP1.7, respectively. RNA in situ hybridization studies of human anagen hair follicles using a conserved probe for these four keratin-associated protein 1 members demonstrated the expression of this group in the differentiated portions of the hair cortex.
毛发纤维分化涉及毛发角蛋白中间丝蛋白及其相关蛋白（称为角蛋白相关蛋白）的表达。在本研究中，从人毛囊mRNA中分离出编码两种新型角蛋白相关蛋白的cDNA克隆。从这些克隆推导的预测氨基酸序列表明，这些蛋白代表人角蛋白相关蛋白1家族的成员。它们与之前描述的两个角蛋白相关蛋白1家族成员hKAP1.1A和hKAP1.1B具有很强的序列同源性。我们分别将这些新蛋白命名为hKAP1.6和hKAP1.7。使用针对这四个角蛋白相关蛋白1成员的保守探针，对人生长期毛囊进行RNA原位杂交研究，结果表明该蛋白家族在毛皮质的分化部分表达。
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