甲氯芬那酸的酰胺衍生物作为选择性环氧化酶-2抑制剂。
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.
作者信息
Kalgutkar Amit S, Rowlinson Scott W, Crews Brenda C, Marnett Lawrence J
机构信息
A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
出版信息
Bioorg Med Chem Lett. 2002 Feb 25;12(4):521-4. doi: 10.1016/s0960-894x(01)00792-2.
Abstract
This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.
摘要
本文描述了通过中和非选择性环氧化酶（COX）抑制剂甲氯芬那酸中的羧基部分，将其转化为强效且选择性的环氧化酶-2（COX-2）抑制剂的构效关系研究。
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