Skoog T, Dichtl W, Boquist S, Skoglund-Andersson C, Karpe F, Tang R, Bond M G, de Faire U, Nilsson J, Eriksson P, Hamsten A
The Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden.
Eur Heart J. 2002 Mar;23(5):376-83. doi: 10.1053/euhj.2001.2805.
Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultrasound examination in a population-based cohort of 96 healthy 50-year-old men.
TNF-alpha and cellular adhesion molecules were measured with enzyme-linked immunosorbent assays. Plasma TNF-alpha concentration was associated with systolic and diastolic blood pressure, degrees of alimentary lipaemia, plasma very low density lipoprotein triglyceride, low density lipoprotein (LDL) cholesterol concentrations and peak LDL particle size. Two indices of insulin resistance as well as all soluble cellular adhesion molecules correlated positively with TNF-alpha. The plasma TNF-alpha concentration was associated with common carotid intima-media thickness in univariate analysis. In contrast, soluble E-selectin and postprandial triglycerides, but not TNF-alpha, were independent determinants of common carotid intima--media thickness.
The plasma TNF-alpha concentration is associated with degrees of early atherosclerosis and correlates with metabolic and cellular perturbations that are considered important for the vascular process.
肿瘤坏死因子-α（TNF-α）是一种促炎细胞因子，与某些代谢紊乱有关，可能在心血管疾病的发生中起作用。我们在一个由96名50岁健康男性组成的基于人群的队列中，研究了血浆TNF-α是否与既定的心血管风险指标、可溶性细胞黏附分子的血浆水平以及通过超声检查测定的颈动脉内膜中层厚度相关。
采用酶联免疫吸附测定法测量TNF-α和细胞黏附分子。血浆TNF-α浓度与收缩压和舒张压、饮食性血脂异常程度、血浆极低密度脂蛋白甘油三酯、低密度脂蛋白（LDL）胆固醇浓度以及LDL颗粒大小峰值相关。两种胰岛素抵抗指标以及所有可溶性细胞黏附分子均与TNF-α呈正相关。在单变量分析中，血浆TNF-α浓度与颈总动脉内膜中层厚度相关。相比之下，可溶性E-选择素和餐后甘油三酯而非TNF-α是颈总动脉内膜中层厚度的独立决定因素。
血浆TNF-α浓度与早期动脉粥样硬化程度相关，并与被认为对血管进程很重要的代谢和细胞紊乱相关。
Zotero 插件