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哺乳期抗感染药物的使用:第二部分——氨基糖苷类、大环内酯类、喹诺酮类、磺胺类、甲氧苄啶、四环素类、氯霉素、克林霉素和甲硝唑

Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole.

作者信息

Chin K G, McPherson C E, Hoffman M, Kuchta A, Mactal-Haaf C

机构信息

University of Illinois, Chicago College of Pharmacy, Chicago, IL, USA.

出版信息

J Hum Lact. 2001 Feb;17(1):54-65. doi: 10.1177/089033440101700111.

Abstract

Because many antibiotics are excreted into breast milk, it can be difficult for a practitioner to choose an antibiotic for a lactating patient that will have minimal risks to her nursing infant. This article is the second of a three-part series discussing the use of anti-infective agents during lactation. The authors review general information regarding use and common side effects for several classes of antibiotics. They also summarize information, including documented milk concentrations, milk-to-plasma ratios, and other pharmacokinetic properties, in a table that can help practitioners choose antibiotics that may be considered safe to use in the lactating mother.

摘要

由于许多抗生素会排泄到母乳中,因此从业者很难为哺乳期患者选择一种对其哺乳婴儿风险最小的抗生素。本文是一个分为三部分的系列文章中的第二篇,讨论哺乳期抗感染药物的使用。作者回顾了几类抗生素的使用及常见副作用的一般信息。他们还在一个表格中总结了相关信息,包括记录的乳汁浓度、乳汁与血浆的比率以及其他药代动力学特性,这有助于从业者选择可能被认为对哺乳期母亲安全使用的抗生素。

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