Odelowo O O, Naab T, Dewitty R L
Division of Gastroenerology, Department of Medicine, Howard University Hospital, 2041 Georgia Avenue, NW, Washington, DC 20060, USA.
J Assoc Acad Minor Phys. 2001 Jul;12(3):144-8.
We report a case of a young man with a rare disease, a choriocarcinoma of the gastrointestinal tract presenting as a common entity, a bleeding duodenal ulcer. Pathological findings and strongly positive immunostains of tissue specimens for beta human chorionic gonadotrophin confirmed the entire tumor to be a choriocarcinoma ruling out the possibility of an adenocarcinoma with focal components of choriocarcinoma or a beta human chorionic gonadotrophin producing adenocarcinoma. The pattern of tumor invasion in this case is more suggestive of metastatic than primary involvement of the gastrointestinal tract. The diagnosis of primary gastrointestinal choriocarcinoma is difficult because of the need to meticulously rule out the occurrence of a primary in other organs, which at times regresses spontaneously, a diagnosis made more difficult in this case in which no autopsy was performed.
我们报告了一例患有罕见疾病的年轻男性病例，其胃肠道绒毛膜癌表现为常见的十二指肠溃疡出血。组织标本的病理检查结果及β-人绒毛膜促性腺激素免疫染色强阳性证实整个肿瘤为绒毛膜癌，排除了腺癌伴绒毛膜癌局灶成分或产生β-人绒毛膜促性腺激素的腺癌的可能性。该病例中肿瘤的侵袭模式更提示为胃肠道的转移而非原发受累。原发性胃肠道绒毛膜癌的诊断较为困难，因为需要仔细排除其他器官原发肿瘤的发生，而其他器官的原发肿瘤有时会自发消退，在本病例中由于未进行尸检，诊断更加困难。
