“……而C代表氯碘羟喹”——阿尔茨海默病的β淀粉样蛋白相关要素。
'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease.
作者信息
Melov Simon
机构信息
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.
出版信息
Trends Neurosci. 2002 Mar;25(3):121-3; discussion 123-4. doi: 10.1016/s0166-2236(00)02086-5.
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder that has been intensively studied over the last several years. In vitro and in vivo studies have led to an understanding of some of the physico-chemical properties of amyloid, a well-characterized hallmark of AD. Clioquinol is a drug that acts on amyloid by perturbing amyloid's metallo-chemistry, and Clioquinol treatment has been shown to be beneficial in a mouse model of AD. This short review examines the recent studies relating to Clioquinol and AD, and anticipates the imminent results of a Phase II trial of Clioquinol in AD, due in March 2002.
阿尔茨海默病（AD）是一种与年龄相关的毁灭性神经退行性疾病，在过去几年中受到了深入研究。体外和体内研究使人们对淀粉样蛋白的一些物理化学性质有了了解，淀粉样蛋白是AD一个特征明确的标志。氯碘羟喹是一种通过干扰淀粉样蛋白的金属化学作用于淀粉样蛋白的药物，并且氯碘羟喹治疗已在AD小鼠模型中显示出有益效果。这篇简短的综述审视了与氯碘羟喹和AD相关的近期研究，并预期了氯碘羟喹治疗AD的II期试验将于2002年3月得出的即将到来的结果。
Zotero 插件