Jawien J
Jagellonian University School of Medicine, Krakow, Poland.
Eur J Clin Invest. 2002 Feb;32(2):134-8. doi: 10.1046/j.0014-2972.2001.00954.x.
In about 10% of adult patients with asthma, aspirin and other nonsteroidal anti-inflammatory drugs precipitate attacks of dyspnoea. Accumulated evidence shows that these reactions are due to the interference of aspirin-like drugs with arachidonic acid metabolism in the lungs of the sensitive patients: inhibition of cyclooxygenase is accompanied by overproduction of cysteinyl leukotrienes. The mechanisms of these reactions and the characteristic course of aspirin-induced asthma and its management are discussed.
在约10%的成年哮喘患者中，阿司匹林和其他非甾体抗炎药会诱发呼吸困难发作。越来越多的证据表明，这些反应是由于阿司匹林类药物干扰了敏感患者肺部的花生四烯酸代谢：环氧合酶受到抑制的同时半胱氨酰白三烯生成过量。本文讨论了这些反应的机制、阿司匹林诱发哮喘的特征病程及其治疗方法。
