胸腺树突状细胞迁移至异基因受体的胸腺并延长移植物存活时间。
Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival.
作者信息
Duncan Steven R, Capetanakis Nickolas G, Lawson Brian R, Theofilopoulos Argyrios N
机构信息
Department of Immunology, The Scripps Research Institute, La Jolla, California, USA.
出版信息
J Clin Invest. 2002 Mar;109(6):755-64. doi: 10.1172/JCI12142.
Abstract
We have demonstrated that murine thymic dendritic cells (DCs) isolated from donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous injections, where they induce T cell deletions and prolong donor-strain airway and skin graft survival. In contrast, infused splenic DCs immigrated poorly to thymi, and did not affect graft survival. These findings suggest that preferential homing may be an important mechanistic difference among subpopulations of DCs that mediate immune functions and illustrate a novel methodology that could have utility for induction of specific immunologic nonreactivity to allografts, or other disease-associated antigens.
摘要
我们已经证明，从供体小鼠分离出的鼠胸腺树突状细胞（DCs）经静脉注射后，有能力归巢至完全异基因受体的胸腺，在那里它们诱导T细胞缺失，并延长供体品系气道和皮肤移植物的存活时间。相比之下，注入的脾脏DCs向胸腺的迁移能力较差，并且不影响移植物存活。这些发现表明，优先归巢可能是介导免疫功能的DCs亚群之间一个重要的机制差异，并阐明了一种新方法，该方法可能有助于诱导对同种异体移植物或其他疾病相关抗原的特异性免疫无反应性。
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