一名低度胶质瘤患者出现与拉莫三嗪相关的粒细胞缺乏症。
Agranulocytosis associated with lamotrigine in a patient with low-grade glioma.
作者信息
Fadul Camilo E, Meyer Louise P, Jobst Barbara C, Cornell Cornelius J, Lewis Lionel D
机构信息
Section of Hematology/Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001, USA.
出版信息
Epilepsia. 2002 Feb;43(2):199-200. doi: 10.1046/j.1528-1157.2002.31801.x.
PURPOSE
To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor.
METHODS
A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously.
RESULTS
After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved.
CONCLUSIONS
In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.
目的
报告1例脑肿瘤患者出现的与拉莫三嗪（LTG）相关的粒细胞缺乏症。
方法
一名59岁患有低度胶质瘤且部分癫痫发作难以控制的女性，在开始服用LTG后9至14周出现粒细胞缺乏症。该患者2年前接受过化疗。
结果
停用LTG后，尽管使用了7天的粒细胞集落刺激因子（G-CSF），粒细胞缺乏症仍持续了9天，最终得以缓解。
结论
在本病例中，使用LTG与粒细胞缺乏症的发生有关，这种关联很可能是因果关系。
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