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来自预处理供体的可透析产物对小鼠淀粉样变性的刺激作用。

Stimulation of murine amyloidosis by a dializable product from pretreated donors.

作者信息

Kedar I, Bleiberg I, Sohar E

出版信息

Br J Exp Pathol. 1975 Jun;56(3):244-6.

Abstract

Amyloid was obtained in recipient mice by implantation into their peritoneal cavity of a dialysis bag containing spleen cells obtained from donor mice which were treated with casein for 6 days and while no amyloid was found in their implanted spleens. The transplantations were performed with 2 cell systems, one containing whole spleen suspension and the other washed cells. Amyloid was obtained in the recipient mice within 6 days after the implantation and in a more massive quantity than in mice treated by casein for a similar period.

摘要

通过将含有从用酪蛋白处理6天的供体小鼠获得的脾细胞的透析袋植入受体小鼠的腹腔中,在受体小鼠中获得了淀粉样蛋白,而在它们植入的脾脏中未发现淀粉样蛋白。移植使用两种细胞系统进行,一种含有全脾悬液,另一种是洗涤过的细胞。在植入后6天内在受体小鼠中获得了淀粉样蛋白,其数量比在相似时间段内用酪蛋白处理的小鼠中更多。

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