Rouse Barry T, Deshpande Shilpa
Department of Microbiology, The University of Tennessee, Knoxville, TN 37996-0845, USA.
Rev Med Virol. 2002 Mar-Apr;12(2):107-13. doi: 10.1002/rmv.347.
Viruses are considered as causative agents and contributors to lesion expression in autoimmune disease, notions best supported by studies in animal model systems. This review discusses relationships between virus infection and autoimmunity focusing on mechanisms by which they could induce autoreactivity. The popular idea of molecular mimicry is viewed skeptically with the reviewers taking the viewpoint that viruses contribute to autoimmunity mainly by inducing several nonspecific inflammatory events that together are sufficient to trigger autoreactivity in genetically receptive hosts.
病毒被认为是自身免疫性疾病中病变表现的致病因素和促成因素,动物模型系统的研究最有力地支持了这些观点。本综述讨论了病毒感染与自身免疫之间的关系,重点关注它们诱导自身反应性的机制。分子模拟这一流行观点受到质疑,综述作者认为病毒主要通过引发一些非特异性炎症事件来促成自身免疫,这些炎症事件共同作用足以在具有遗传易感性的宿主中触发自身反应性。