Cos P, Hermans N, De Bruyne T, Apers S, Sindambiwe J B, Witvrouw M, De Clercq E, Vanden Berghe D, Pieters L, Vlietinck A J
Faculty of Pharmaceutical Sciences, University of Antwerp, Belgium.
Phytomedicine. 2002 Jan;9(1):62-8. doi: 10.1078/0944-7113-00083.
Selected plants used in Rwandan traditional medicine for the treatment of infections and/or rheumatoid diseases were investigated for antiviral activity in vitro against human immunodeficiency virus type-1 (HIV-1). Of the 38 tested 80% ethanolic extracts, belonging to plants of 21 different families only the extracts from the leaves of Aspilia pluriseta (Asteraceae) and Rumex bequaertii (Polygonaceae) had interesting selectivity indices (SI = ratio of the 50% cytotoxic concentration to the 50% effective antiviral concentration) higher than 1. Further fractionation of the initially antivirally inactive ethanolic extract of Tithonia diversifolia, however, led to an aqueous fraction with a high anti-HIV-1 activity (SI > 461), indicating that the cytotoxicity of some plant components may mask the antiviral properties of the active plant substances in total plant extracts.
对卢旺达传统医学中用于治疗感染和/或类风湿疾病的选定植物进行了体外抗人免疫缺陷病毒1型（HIV-1）的抗病毒活性研究。在测试的属于21个不同科植物的38种80%乙醇提取物中，只有多裂阿斯皮利亚（菊科）和贝氏酸模（蓼科）叶子的提取物具有高于1的有趣选择性指数（SI = 50%细胞毒性浓度与50%有效抗病毒浓度之比）。然而，对最初无抗病毒活性的异叶肿柄菊乙醇提取物进行进一步分级分离后，得到了一种具有高抗HIV-1活性（SI > 461）的水相部分，这表明某些植物成分的细胞毒性可能会掩盖植物提取物中活性植物物质的抗病毒特性。
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