拟精神病性苯异丙胺。5. 4-烷基-2,5-二甲氧基苯异丙胺。
Psychotomimetic phenylisopropylamines. 5. 4-Alkyl-2,5-dimethoxyphenylisopropylamines.
作者信息
Shulgin A T, Dyer D C
出版信息
J Med Chem. 1975 Dec;18(12):1201-4. doi: 10.1021/jm00246a006.
PMID:1195275
Abstract
A homologous series of 4-alkyl-2,5-dimethoxyphenylisopropylamines (alkyl = H through n-C5H11 and t-C4H9) was synthesized and compared with mescaline as serotonin agonists in a sheep umbilical preparation. The three-carbon homolog 6d was found to be the most potent of the straight-chain series in accordance with its observed psychotomimetic effectiveness in man.
摘要
合成了一系列4-烷基-2,5-二甲氧基苯异丙胺（烷基从H到正戊基和叔丁基），并在羊脐带制剂中作为5-羟色胺激动剂与三甲氧苯乙胺进行比较。根据其在人体中观察到的拟精神病作用效果，发现三碳同系物6d是直链系列中最有效的。
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