Ly49自然杀伤细胞受体对MHC I类分子的识别

MHC class I recognition by Ly49 natural killer cell receptors.

作者信息

Natarajan Kannan, Dimasi Nazzareno, Wang Jian, Margulies David H, Mariuzza Roy A

机构信息

Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA.

出版信息

Mol Immunol. 2002 May;38(14):1023-7. doi: 10.1016/s0161-5890(02)00031-7.

DOI:10.1016/s0161-5890(02)00031-7

PMID:11955594

Abstract

Natural killer (NK) cell function is regulated by NK receptors that bind either classical MHC class I (MHC-I) molecules or their structural relatives (MICA, RAE-1 and H-60). Two distinct families of NK receptors have been identified: the C-type lectin-like family (Ly49, NKG2D and CD94/NKG2) and the immunoglobulin-like family (KIRs and LIRs). Here, we describe the crystal structure of the C-type lectin-like NK receptor (Ly49A), bound to its MHC-I ligand (H-2D(d)). We also discuss results from recent mutagenesis studies of the Ly49A/H-2D(d) interaction in the context of the complex structure.

摘要

自然杀伤（NK）细胞的功能由自然杀伤细胞受体调节，这些受体可与经典的MHC I类（MHC-I）分子或其结构相关分子（MICA、RAE-1和H-60）结合。已鉴定出两个不同的自然杀伤细胞受体家族：C型凝集素样家族（Ly49、NKG2D和CD94/NKG2）和免疫球蛋白样家族（KIR和LIR）。在此，我们描述了与MHC-I配体（H-2D(d)）结合的C型凝集素样自然杀伤细胞受体（Ly49A）的晶体结构。我们还在复合物结构的背景下讨论了Ly49A/H-2D(d)相互作用的近期诱变研究结果。