Engedal Knut
Nasjonalt kompetansesenter for aldersdemens Ullevål universitetssykehus 0407 Oslo.
Tidsskr Nor Laegeforen. 2002 Feb 20;122(5):520-4.
Dementia is one of the most common conditions in the elderly. In Norway the total prevalence is about 60,000.
The paper is based on the author's clinical experience and a review of the literature.
No biological marker exists for Alzheimer's disease and other dementias. The diagnostic work-up thus consists of a comprehensive clinical neuropsychological, physical and psychiatric examination. Imaging of the brain could be useful in the differential diagnostic work-up. In mild cases and cases of suspected dementia, the work-up is carried out in specialist health care. Moderate and severe cases are assessed on primary care. There is currently no cure for dementia disorders, although acetylcholinesterase inhibitors may prove effective for Alzheimer's disease and Lewy body dementia. Behavioural and psychiatric symptoms can be pharmacologically treated.
A careful diagnostic work-up must be carried out to diagnose dementia. Symptomatic treatment is available and should be initiated.
痴呆是老年人中最常见的病症之一。在挪威,其总患病率约为60000例。
本文基于作者的临床经验及文献综述。
阿尔茨海默病和其他痴呆症不存在生物学标志物。因此,诊断检查包括全面的临床神经心理学、体格和精神检查。脑部成像在鉴别诊断检查中可能有用。在轻度病例和疑似痴呆病例中,检查在专科医疗保健机构进行。中度和重度病例在初级保健机构进行评估。目前尚无治愈痴呆症的方法,尽管乙酰胆碱酯酶抑制剂可能对阿尔茨海默病和路易体痴呆有效。行为和精神症状可用药物治疗。
必须进行仔细的诊断检查以诊断痴呆。有对症治疗方法,应予以启动。