染色体V(D)J重组的机制与调控。
The mechanism and regulation of chromosomal V(D)J recombination.
作者信息
Bassing Craig H, Swat Wojciech, Alt Frederick W
机构信息
Howard Hughes Medical Institute, The Children's Hospital, The Center for Blood Research, Boston, MA 02115, USA.
出版信息
Cell. 2002 Apr;109 Suppl:S45-55. doi: 10.1016/s0092-8674(02)00675-x.
Abstract
V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.
摘要
V(D)J重排对于多样化抗原受体库的产生至关重要。我们回顾了目前对V(D)J重排反应及其在淋巴细胞发育过程中如何受到调控的理解。我们还讨论了V(D)J重排机制或调控中的缺陷如何导致人类疾病。
Zotero 插件