Synthesis and Antihypertensive Activities of New 1, 4-Dihydropyridine Containing Nitroimidazolyl Substituent with a Nitrooxy Group at the 3-Ester Position.
作者信息
Shafiee Abbas, Rastkary Noushin, Jorjani Masoumeh, Shafaghi Bijan
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Arch Pharm (Weinheim). 2002 May;335(2):69-76. doi: 10.1002/1521-4184(200205)335:2<69::AID-ARDP69>3.0.CO;2-6.
Abstract
New analogues of nifedipine, in which the ortho nitrophenyl group of position 4 is replaced by 1-methyl-4-nitro-5-imidazolyl or 1-methyl-5-imidazolyl with a nitrooxy group at the 3-ester position were synthesized, and the antihypertensive activity of the compounds was examined by the tail-cuff method and compared with TNG and nifedipine. Compounds 11g, 11i-11m, 110, 11r, and 11v showed activity similar to nifedipine and TNG.
摘要
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