Bonhoeffer Philipp, Boudjemline Younes, Qureshi Shakeel A, Le Bidois Jerome, Iserin Laurence, Acar Philippe, Merckx Jacques, Kachaner Jean, Sidi Daniel
Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
J Am Coll Cardiol. 2002 May 15;39(10):1664-9. doi: 10.1016/s0735-1097(02)01822-3.
We report our experience of percutaneous valve insertion in pulmonary position in humans.
Over the past 40 years, prosthetic conduits have been developed to surgically establish continuity between the right ventricle and the pulmonary artery. However, stenosis and insufficiency of the conduit due to valvular degeneration or panus ingrowth frequently occur, limiting patients' lifespan. Percutaneous stenting of conduits has recently emerged as a technique for delaying surgical replacement, but it creates a pulmonary regurgitation when crossing the valve.
Seven children and one adult with stenosis and/or insufficiency of the pulmonary graft underwent percutaneous implantation of a bovine jugular valve in pulmonary position.
Percutaneous pulmonary valve (PV) replacement was successful in all patients. No complications occurred in early follow-up. Angiography, hemodynamic studies and echocardiography after the procedure showed no significant regurgitation of the implanted valve. Implantation was effective in relieving the obstruction in five patients. All patients showed improvement in their clinical status at the latest follow-up (mean 10.1 months).
Non-surgical insertion of the PV is possible without any major complications. This new technique may have an important role in the management of conduit obstructions and pulmonary regurgitation.
我们报告人类经皮肺动脉瓣置入的经验。
在过去40年中,已研发出人工血管以手术方式建立右心室与肺动脉之间的连接。然而,由于瓣膜退变或血管翳长入导致的人工血管狭窄和功能不全经常发生,限制了患者的寿命。最近,经皮人工血管支架置入术作为一种延迟手术置换的技术出现,但在穿过瓣膜时会产生肺动脉反流。
7名儿童和1名成人因肺动脉移植血管狭窄和/或功能不全接受了经皮肺动脉位牛颈静脉瓣植入术。
所有患者经皮肺动脉瓣置换均成功。早期随访未发生并发症。术后血管造影、血流动力学研究和超声心动图显示植入瓣膜无明显反流。植入术有效缓解了5例患者的梗阻。所有患者在最近一次随访(平均10.1个月)时临床状况均有改善。
经皮肺动脉瓣置入术可行且无任何重大并发症。这项新技术可能在人工血管梗阻和肺动脉反流的治疗中发挥重要作用。