Boshoff Chris, Weiss Robin
Viral Oncology Group, Wolfson Institute for Biomedical Research, University College, London, UK.
Nat Rev Cancer. 2002 May;2(5):373-82. doi: 10.1038/nrc797.
Cancer remains a significant burden for human immunodeficiency virus (HIV)-infected individuals. Most cancers that are associated with HIV infection are driven by oncogenic viruses, such as Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus and human papillomavirus. Gaining insight into the epidemiology and mechanisms that underlie AIDS-related cancers has provided us with a better understanding of cancer immunity and viral oncogenesis.
癌症仍然是人类免疫缺陷病毒(HIV)感染者的一项重大负担。大多数与HIV感染相关的癌症是由致癌病毒驱动的,如爱泼斯坦-巴尔病毒、卡波西肉瘤相关疱疹病毒和人乳头瘤病毒。深入了解艾滋病相关癌症的流行病学和潜在机制,使我们对癌症免疫和病毒致癌作用有了更好的理解。