局部晚期胰腺癌的管理

Management of locally advanced adenocarcinoma of the pancreas.

作者信息

Ryan David P, Willett Christopher G

机构信息

Gastrointestinal Cancer Center, Massachusetts General Hospital, Harvard Medical School, Cox 640, 100 Blossom Street, Boston, MA 02114, USA.

出版信息

Hematol Oncol Clin North Am. 2002 Feb;16(1):95-103. doi: 10.1016/s0889-8588(01)00009-0.

DOI:10.1016/s0889-8588(01)00009-0

PMID:12063831

Abstract

Pancreatic cancer is one of the deadliest malignancies and is fatal in more than 95% of affected individuals. For locally advanced disease, the combination of 5-FU and radiation appears to offer the best chance for delaying disease progression. The introduction of gemcitabine into chemoradiotherapy regimens may provide additional improvements in the management of patients. Preoperative therapy has proved feasible but has not shown improvement in overall survival.

摘要

胰腺癌是最致命的恶性肿瘤之一，超过95%的患者会因此死亡。对于局部晚期疾病，5-氟尿嘧啶与放疗联合使用似乎是延缓疾病进展的最佳选择。将吉西他滨引入放化疗方案可能会进一步改善患者的治疗效果。术前治疗已被证明是可行的，但总体生存率并未得到改善。