Gerber D A
J Rheumatol. 1975 Dec;2(4):384-92.
The serum concentrations of 12 free amino acids (alanine, arginine, glycine, histidine, isoleucine, leucine, lysine, phenylalanine, serine, threonine, tyrosine, and valine) were measured in 26 patients with rheumatoid arthritis and in 12 control subjects. Patients with rheumatoid arthritis had a low serum histidine concentration (P equals 0.002) but no abnormality of any other amino acid concentration or of the combined concentration of the measured amino acids, excluding histidine. These data and 22 other reported studies provide strong evidence for the presence of hypohistidemia, not associated with generalized hypoaminoacidemia, in patients with rheumatoid arthritis. (J Rheumatol 2: 384-392, 1975).
测定了26例类风湿性关节炎患者和12例对照者血清中12种游离氨基酸（丙氨酸、精氨酸、甘氨酸、组氨酸、异亮氨酸、亮氨酸、赖氨酸、苯丙氨酸、丝氨酸、苏氨酸、酪氨酸和缬氨酸）的浓度。类风湿性关节炎患者血清组氨酸浓度较低（P = 0.002），但除组氨酸外，其他任何氨基酸浓度或所测氨基酸的联合浓度均无异常。这些数据以及其他22项已发表的研究为类风湿性关节炎患者存在低组氨酸血症提供了有力证据，且低组氨酸血症与全身性低氨基酸血症无关。（《风湿病学杂志》2: 384 - 392, 1975）
Zotero 插件