手术及术后使用甲苯咪唑治疗包虫病。

Ammari Fuad F, Omari Abdel K

Department of General Surgery, Faculty of Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan.

Saudi Med J. 2002 May;23(5):568-71.

OBJECTIVE

Surgery was virtually the only curative method for hydatid disease until the early 1970s when studies have shown the safety and effectiveness of benzomidazole compounds for the treatment of hydatid cysts. Our aim is to establish the outcome of chemotherapy in the postoperative period on secondary hydatid cyst.

METHODS

Between 1987 to 1996 inclusive, all patients who were diagnosed with hepatic hydatid disease and who underwent surgery and received a post operative course of chemotherapy at Princess Basma Teaching Hospital, Irbid, North Jordan, were retrospectively reviewed with special referral to side effects of chemotherapy and recurrence rate of hydatid disease.

RESULTS

There were 78 patients (41 females, 37 males). All age groups were involved with an age range of 8-70 years. The main clinical presentation was upper abdominal discomfort, heaviness and mild pain. Ultrasonography and indirect hemagglutination test diagnosed more than 90% of cases. All patients were operated upon and received a postoperative prophylactic course of mebendazole. We reported a recurrence rate of less than 3%. Excessive loss of hair as a side effect to mebendazole therapy occurred in 2 young female patients.

CONCLUSION

The postoperative prophylactic course of mebendazole is reliable, safe and with minor side effects and the recurrence rate of the disease was reduced to the lowest possible levels.

目的

直到20世纪70年代初，手术实际上是治疗包虫病的唯一治愈方法，当时的研究表明苯并咪唑化合物治疗包虫囊肿具有安全性和有效性。我们的目的是确定术后化疗对继发性包虫囊肿的治疗效果。

方法

回顾性分析1987年至1996年期间，在约旦北部伊尔比德的巴斯玛公主教学医院被诊断为肝包虫病并接受手术及术后化疗的所有患者，特别关注化疗的副作用和包虫病的复发率。

结果

共有78例患者（41例女性，37例男性）。各年龄组均有涉及，年龄范围为8至70岁。主要临床表现为上腹部不适、沉重感和轻度疼痛。超声检查和间接血凝试验诊断出90%以上的病例。所有患者均接受了手术，并接受了术后甲苯咪唑预防性治疗。我们报告的复发率低于3%。2例年轻女性患者出现了作为甲苯咪唑治疗副作用的过度脱发。