在非锥体外系脑部疾病中，黑质回声正常，但在帕金森病中黑质回声增强。
Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders but increased in Parkinson's disease.
作者信息
Walter U, Wittstock M, Benecke R, Dressler D
机构信息
Department of Neurology, Rostock University, Federal Republic of Germany.
出版信息
J Neural Transm (Vienna). 2002 Feb;109(2):191-6. doi: 10.1007/s007020200015.
Transcranial sonography (TCS) revealed substantia nigra (SN) hyperechogenicity in idiopathic Parkinson's disease (IPD). To further evaluate specificity of this finding, we examined 30 IPD patients and 30 age-matched subjects with non-extrapyramidal cerebral disorders (NED). All IPD patients showed a SN hyperechogenicity, in 17 it was bilateral and in 13 unilateral. 7 NED patients had a SN hyperechogenicity, in all it was unilateral, confirming previous results in healthy subjects. Bilateral SN hyperechogenicity indicates IPD and normal SN echogenicity indicates NED. In 30% of patients TCS does not distinguish between IPD and NED. Data further support the assumption that bilateral SN hyperechogenicity is specific for IPD.
经颅超声检查（TCS）显示，特发性帕金森病（IPD）患者存在黑质（SN）回声增强。为进一步评估这一发现的特异性，我们对30例IPD患者和30例年龄匹配的非锥体外系脑部疾病（NED）患者进行了检查。所有IPD患者均表现出SN回声增强，其中17例为双侧，13例为单侧。7例NED患者存在SN回声增强，均为单侧，这证实了之前在健康受试者中的研究结果。双侧SN回声增强提示IPD，而正常SN回声提示NED。在30%的患者中，TCS无法区分IPD和NED。这些数据进一步支持了双侧SN回声增强对IPD具有特异性的假设。
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