Hilde G, Hagen K B, Jamtvedt G, Winnem M
Health Services Research Unit, National Institute of Public Health, P.O. Box 4404 Torshov, N-0403 Oslo, Norway.
Cochrane Database Syst Rev. 2002(2):CD003632. doi: 10.1002/14651858.CD003632.
Low back pain is one of the most common conditions managed in primary care. Restricted activity, rest, and symptomatic analgesics are the most commonly prescribed treatment for low back pain and sciatica.
To assess the effects of advice to stay active as single treatment for patients with low back pain.
Computerised searches in MEDLINE, EMBASE, Sport, The Cochrane Controlled Trials Register, Musculoskeletal Group's Trials Register and Scisearch, and scanning of reference lists from relevant articles were undertaken. Relevant studies were also traced by contacting authors. Date of the most recent searches: December 1998.
We included all randomised trials or quasi-randomised trials where the study population consisted of adult patients with low back pain or sciatica, in which one comparison group was advised to stay active. The main outcomes of interest were pain, functional status, recovery and return to work.
Two reviewers independently selected trials for inclusion, assessed the validity of included trials and extracted data. Investigators were contacted to collect missing data or for clarification when needed.
Four trials, with a total of 491 patients, were included. Advice to stay active was compared to advice to rest in bed in all trials. Two trials were assessed to have low risk of bias and two to have moderate to high risk of bias. The results were heterogeneous. Results from one high quality trial of patients with acute simple LBP found small differences in functional status [Weighted Mean Difference (on a 0-100 scale) 6.0 (95% CI: 1.5, 10.5)] and length of sick leave [WMD 3.4 days (95% CI: 1.6, 5.2)] in favour of staying active compared to advice to stay in bed for two days. The other high quality trial compared advice to stay active with advice to rest in bed for 14 days for patients with sciatic syndrome, and found no differences between the groups. One of the high quality trials also compared advice to stay active with exercises for patients with acute simple LBP, and found improvement in functional status and reduction in sick leave in favour of advice to stay active.
REVIEWER'S CONCLUSIONS: The best available evidence suggests that advice to stay active alone has small beneficial effects for patients with acute simple low back pain, and little or no effect for patients with sciatica. There is no evidence that advice to stay active is harmful for either acute low back pain or sciatica. If there is no major difference between advice to stay active and advice to rest in bed, and there is potential harmful effects of prolonged bed rest, then it is reasonable to advise people with acute low back pain and sciatica to stay active. These conclusions are based on single trials.
腰痛是基层医疗中最常见的病症之一。限制活动、休息以及对症使用镇痛药是治疗腰痛和坐骨神经痛最常用的方法。
评估建议保持活动作为腰痛患者单一治疗方法的效果。
对MEDLINE、EMBASE、Sport、Cochrane对照试验注册库、肌肉骨骼组试验注册库和Scisearch进行计算机检索,并查阅相关文章的参考文献列表。还通过联系作者追踪相关研究。最近一次检索日期:1998年12月。
我们纳入了所有随机试验或半随机试验,研究人群为患有腰痛或坐骨神经痛的成年患者,其中一个比较组被建议保持活动。主要关注的结局是疼痛、功能状态、恢复情况和重返工作岗位。
两名综述作者独立选择纳入试验,评估纳入试验的有效性并提取数据。必要时联系研究者收集缺失数据或进行澄清。
共纳入4项试验,总计491名患者。在所有试验中,将建议保持活动与建议卧床休息进行了比较。两项试验被评估为偏倚风险低,两项试验被评估为偏倚风险中度至高度。结果存在异质性。一项针对急性单纯性腰痛患者的高质量试验结果显示,与建议卧床休息两天相比,保持活动在功能状态方面有小的差异[加权均数差(0 - 100分制)6.0(95%可信区间:1.5,10.5)],病假时长方面也有差异[加权均数差3.4天(95%可信区间:1.6,5.2)],保持活动更有利。另一项高质量试验将坐骨神经综合征患者保持活动的建议与卧床休息14天的建议进行了比较,发现两组之间没有差异。其中一项高质量试验还将急性单纯性腰痛患者保持活动的建议与锻炼进行了比较,发现保持活动的建议在功能状态改善和病假天数减少方面更有利。
现有最佳证据表明,仅建议保持活动对急性单纯性腰痛患者有小的有益效果,对坐骨神经痛患者几乎没有效果或没有效果。没有证据表明建议保持活动对急性腰痛或坐骨神经痛有害。如果建议保持活动和建议卧床休息之间没有重大差异,且长期卧床休息存在潜在有害影响,那么建议急性腰痛和坐骨神经痛患者保持活动是合理的。这些结论基于单项试验。