鹅掌楸内酯A - F，从景洪哥纳香根中分离得到的6个新的苯乙烯基吡喃酮衍生物。

Goniolactones A-F, six new styrylpyrone derivatives from the roots of Goniothalamus cheliensis.

作者信息

Wang Si, Zhang Yan-Jun, Chen Ruo-Yun, Yu De-Quan

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

出版信息

J Nat Prod. 2002 Jun;65(6):835-41. doi: 10.1021/np010443w.

DOI:10.1021/np010443w

PMID:12088424

Abstract

Six new styrylpyrone derivatives, goniolactones A-F (1-6), have been isolated from the roots of Goniothalamus cheliensis. The structures and stereochemistry of the new compounds were elucidated by interpretation of spectroscopic data and chemical methods. The relative configuration of goniolactone A (1) was determined by X-ray crystallography analysis, and the absolute configurations of goniolactones A (1) and B (2) were established by Mosher's method. Goniolactone B (2) exhibited significant cytotoxicity against A2780, HCT-8, and KB cells with IC(50) values of 7.40, 4.43, and 7.23 microM, respectively.

摘要

从海南哥纳香的根部分离出了六种新的苯乙烯基吡喃酮衍生物，哥纳香内酯A - F（1 - 6）。通过光谱数据解析和化学方法阐明了新化合物的结构和立体化学。哥纳香内酯A（1）的相对构型通过X射线晶体学分析确定，哥纳香内酯A（1）和B（2）的绝对构型通过莫舍尔方法确定。哥纳香内酯B（2）对A2780、HCT - 8和KB细胞表现出显著的细胞毒性，IC（50）值分别为7.40、4.43和7.23微摩尔。