老年SAMP8小鼠磨牙拔除后海马隔区胆碱能系统的变化
Changes in the septohippocampal cholinergic system following removal of molar teeth in the aged SAMP8 mouse.
作者信息
Onozuka Minoru, Watanabe Kazuko, Fujita Masafumi, Tomida Mihoko, Ozono Satoru
机构信息
Department of Anatomy (2nd Division), Gifu University School of Medicine, 40 Tsukasa-machi, Japan.
出版信息
Behav Brain Res. 2002 Jul 18;133(2):197-204. doi: 10.1016/s0166-4328(02)00006-2.
We investigated the effect of dysfunctional teeth on age-related changes in the septohippocampal cholinergic system by assessing acetylcholine (ACh) release and choline acetyltransferase (ChAT) activity in the hippocampus and ChAT immunohistochemistry in the medial septal nucleus and the vertical limb of the diagonal band in young-adult and aged SAMP8 mice after removal of their upper molar teeth (molarless condition). Aged molarless mice showed decreased ACh release and ChAT activity in the hippocampus and a reduced number of ChAT-immunopositive neurons in the medial septal nucleus compared to age-matched control mice, whereas these effects were not seen in young-adult mice. The results suggest that the molarless condition in aged SAMP8 mice may enhance an age-related decline in the septohippocampal cholinergic system.
我们通过评估年轻成年和老年SAMP8小鼠在上颌磨牙拔除后（无磨牙状态）海马中的乙酰胆碱（ACh）释放和胆碱乙酰转移酶（ChAT）活性，以及内侧隔核和斜角带垂直支中的ChAT免疫组织化学，研究了功能失调的牙齿对隔海马胆碱能系统年龄相关变化的影响。与年龄匹配的对照小鼠相比，老年无磨牙小鼠海马中的ACh释放和ChAT活性降低，内侧隔核中ChAT免疫阳性神经元数量减少，而在年轻成年小鼠中未观察到这些影响。结果表明，老年SAMP8小鼠的无磨牙状态可能会加剧隔海马胆碱能系统与年龄相关的衰退。
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