后生动物中的可变前体mRNA剪接与蛋白质组扩展

Alternative pre-mRNA splicing and proteome expansion in metazoans.

作者信息

Maniatis Tom, Tasic Bosiljka

机构信息

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

出版信息

Nature. 2002 Jul 11;418(6894):236-43. doi: 10.1038/418236a.

DOI:10.1038/418236a

PMID:12110900

Abstract

The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing selectively joins different protein coding elements to form mRNAs that encode proteins with distinct functions, and is therefore an important source of protein diversity. The elaboration of this mechanism may have had a significant role in the expansion of metazoan proteomes during evolution.

摘要

大多数真核生物信使核糖核酸前体（前体mRNA）的蛋白质编码序列被称为内含子的非编码序列所中断。前体mRNA剪接是去除内含子并将蛋白质编码元件组装成成熟mRNA的过程。可变前体mRNA剪接选择性地连接不同的蛋白质编码元件，以形成编码具有不同功能蛋白质的mRNA，因此是蛋白质多样性的重要来源。这一机制的精细调控在进化过程中后生动物蛋白质组的扩展中可能发挥了重要作用。